Kyu Pill Kim, Jong Sung Kim, Sung Soo Kim, Jin Kyu Jung, Seok Joon Yoon, Chang Jung Wei
Department of Family Medicine, Research Institute for Medical Sciences, Chungnam National University
School of Medicine, Daejeon, Korea
Background: Facial flushing response to drinking is observed in East Asians with deficient activity of the variant
aldehyde dehydrogenase 2 genotype. This study examined the role of flushing response in the relationship between
alcohol consumption and dyslipidemia.
Methods: This cross-sectional study included 1,443 Korean men, including 261 non-drinkers, 470 flushers and
712 non-flushers. Based on a questionnaire, weekly alcohol consumption was assessed and categorized into
4 groups. Dyslipidemia was defined by the National Cholesterol Education Program-Adult Treatment Panel III
criteria. After adjusting for confounding factors, we evaluated the relationship between weekly alcoholic drinks
and dyslipidemia in flushers and non-flushers by comparing with non-drinkers, using a multi-variable logistic regression
analysis.
Results: Non-flushers had a significant relationship between hypertriglyceridemia and alcohol consumption in
two groups (4-8 drinks: adjusted odds ratio [aOR] 1.937, 95% confidence interval [CI] 1.029-3.644; ¡Ã16 drinks:
aOR 2.118, 95% CI 1.272-3.527) in contrast to flushers, who showed no significant relationship between hypertriglyceridemia
and alcohol consumption. Non-flushers had a significant relationship to low serum high density
lipoprotein (HDL) cholesterol levels in four groups (<4 drinks: aOR 0.428, 95% CI 0.277-0.662; 4-8 drinks: aOR
0.409, 95% CI 0.216-0.774; 8-16 drinks: aOR 0.285, 95% CI 0.152-0.536; ¡Ã16 drinks: aOR 0.343, 95% CI
0.207-0.568), and flushers had a significant relationship in two groups (8-16 drinks: aOR 0.234, 95% CI
0.102-0.536; ¡Ã16 drinks: aOR 0.342, 95% CI 0.166-0.705).
Conclusions: Our results suggest that drinking alcohol increases the risk of hypertriglyceridemia in non-flushers
and the risk of low HDL cholesterol flushers.
Korean J Health Promot 2016;16(3):153-161
Keywords: Alcohol drinking, Flushing, Dyslipidemias, High density lipoprotein cholesterol, Triglycerides |