김선미

강원대학교 의과대학 가정의학교실 강원대학교병원 가정의학과

Background: Serum uric acid levels have been reported to
be associated with various conditions including
psoriasis and metabolic syndrome, but their relationship with
atopic dermatitis has not been studied
adequately. This study aimed to investigate the association
of atopic dermatitis with serum uric acid level and
hyperuricemia in adult females and males.
Methods: Using data from the 7th and 8th Korea National
Health and Nutrition Examination Survey, multiple lin-
ear and logistic regression analyses were performed to
assess the association of atopic dermatitis with serum
uric acid level and hyperuricemia respectively, with
adjustment for potential confounding factors in females and
males aged 19 years or older, respectively.
Results: The study population included 14,504 female and
12,147 male participants. When adjusting for poten-
tial confounding factors, females with atopic dermatitis had a
mean serum uric acid level of 0.13 mg/dL (95%
confidence interval [CI], 0.03-0.24) higher than those
without atopic dermatitis (P=0.013), and hyperuricemia
was also more frequent in females with atopic dermatitis
than those without atopic dermatitis (adjusted odds ra-
tio, 1.86; 95% CI, 1.27-2.72; P=0.002). On the other hand,
there were no significant differences in mean serum
uric acid level and frequency of hyperuricemia between
males with and without atopic dermatitis when adjust-
ing for potential confounding factors.
Conclusions: These results show a close relationship of
atopic dermatitis with elevated serum uric acid level
and hyperuricemia in Korean adult females but not males.
Korean J Health Promot 2023;23(4):198-208
Keywords: Atopic dermatitis, Uric acid, Hyperuricemia